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The First Cohort

Medical research, with the receipts

Cancer

A Korean lab found cancer’s DNA-repair off-switch. In a mouse.

A tool compound strips the DNA-repair proteins tumors use to dodge PARP inhibitors. Preclinical only — but the gap between treated and control animals is the story.

Lena Marshall  ·  6 min read

TUMOR CLEARANCE AT 8 WEEKS 94% 12% Treated Control Source: Korean Institute preclinical data

Today’s index

Cancer

ALTAIR missed its endpoint. The press tour found something else.

Metabolic

Where your sodium actually comes from

Autoimmune

Fish oil rewired the T-cells in non-obese diabetic rats

Drugs & FDA

Europe had this sunscreen in 1999. The FDA approved it Tuesday.

Infectious Disease

A DoD-funded fentanyl vaccine is headed to Phase 1

Brain & Aging

The Alzheimer’s drug that bets the plaques are a symptom

Nutrition

The thin trial behind England’s next supermarket-layout mandate

Investigations

A Senate subcommittee just put the COVID-shot cancer question on the record

The $401 CBC and the $32 CBC are the same test

A 16-foot fire tornado burned an oil slick with 40% less soot